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Title:

Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Li, Q; Csanády, GA; Kessler, W; Klein, D; Pankratz, H; Putz, C; Richter, N; Filser, JG
Abstract:
Ethylene (ET) is metabolized in mammals to the carcinogenic ethylene oxide (EO). Although both gases are of high industrial relevance, only limited data exist on the toxicokinetics of ET in mice and of EO in humans. Metabolism of ET is related to cytochrome P450-dependent mono-oxygenase (CYP) and of EO to epoxide hydrolase (EH) and glutathione S-transferase (GST). Kinetics of ET metabolism to EO and of elimination of EO were investigated in headspace vessels containing incubations of subcellular...     »
Journal title abbreviation:
Toxicol Sci
Year:
2011
Journal volume:
123
Journal issue:
2
Pages contribution:
384-98
Language:
eng
Fulltext / DOI:
doi:10.1093/toxsci/kfr194
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21785163
Print-ISSN:
1096-6080
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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