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Title:

Evidence against a major role for TKTL-1 in hypoxic and normoxic cancer cells.

Document type:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Mayer, A; Von Wallbrunn, A; Vaupel, P
Abstract:
Based on studies performed with a selected mouse monoclonal anti-transketolase- like (TKTL)-1 antibody (clone JFC12T10), overexpression of TKTL-1 has been shown to be correlated with poor survival and increased metastatic spread in several human tumor entities. Since the clinical aggressiveness mediated by TKTL-1 has been partially related to resistance to hypoxia,we originally aimed to explore the influence of hypoxia on the expression of TKTL-1. Unexpectedly, results of our experiments indicat...     »
Journal title abbreviation:
Adv Exp Med Biol
Year:
2011
Journal volume:
701
Pages contribution:
123-8
Language:
eng
Fulltext / DOI:
doi:10.1007/978-1-4419-7756-4_17
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21445778
Print-ISSN:
0065-2598
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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