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Title:

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Stangl, S; Gehrmann, M; Riegger, J; Kuhs, K; Riederer, I; Sievert, W; Hube, K; Mocikat, R; Dressel, R; Kremmer, E; Pockley, AG; Friedrich, L; Vígh, L; Skerra, A; Multhoff, G
Abstract:
Immunization of mice with a 14-mer peptide TKDNNLLGRFELSG, termed "TKD," comprising amino acids 450-461 (aa(450-461)) in the C terminus of inducible Hsp70, resulted in the generation of an IgG1 mouse mAb cmHsp70.1. The epitope recognized by cmHsp70.1 mAb, which has been confirmed to be located in the TKD sequence by SPOT analysis, is frequently detectable on the cell surface of human and mouse tumors, but not on isogenic cells and normal tissues, and membrane Hsp70 might thus serve as a tumor-sp...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2011
Journal volume:
108
Journal issue:
2
Pages contribution:
733-8
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1016065108
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21187371
Print-ISSN:
0027-8424
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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