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Titel:

EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hoffmann, J; Junker, H; Schmieder, A; Venz, S; Brandt, R; Multhoff, G; Falk, W; Radons, J
Abstract:
Human pancreatic cancer is currently one of the fifth-leading causes of cancer-related mortality with a 5-year survival rate of less than 5%. Since pancreatic carcinoma is largely refractory to conventional therapies, there is a strong medical need for the development of novel and innovative therapeutic strategies. Increasing evidence suggests an association of carcinogenesis and chronic inflammation. Because IL-1 plays a crucial role in inflammation-associated carcinogenesis, we analyzed the bi...     »
Zeitschriftentitel:
Biochem Pharmacol
Jahr:
2011
Band / Volume:
82
Heft / Issue:
9
Seitenangaben Beitrag:
1153-62
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.bcp.2011.07.063
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21787753
Print-ISSN:
0006-2952
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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