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Title:

Immunostimulation of bronchoalveolar lavage cells from recurrent airway obstruction-affected horses by different CpG-classes bound to gelatin nanoparticles.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Klier, J; May, A; Fuchs, S; Schillinger, U; Plank, C; Winter, G; Gehlen, H; Coester, C
Abstract:
Recurrent airway obstruction (RAO) in horses has become a common problem in stabled horses in industrialized countries and deserves new therapeutic strategies. CpG-oligodeoxynucleotides (CpG-ODNs) were developed as effective immunostimulating agents to induce a Th2/Th1 shift. These agents showed a beneficial therapeutic effect in allergic diseases with predominant Th2 immunoresponse. CpG-ODN delivery by gelatin nanoparticles (GNPs) resulted in enhanced cellular uptake in murine and human in vitr...     »
Journal title abbreviation:
Vet Immunol Immunopathol
Year:
2011
Journal volume:
144
Journal issue:
1-2
Pages contribution:
79-87
Language:
eng
Fulltext / DOI:
doi:10.1016/j.vetimm.2011.07.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21831455
Print-ISSN:
0165-2427
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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