Can Immunoglobulin E-measurement replace challenge tests in allergic rhinoconjunctivits to grass pollen?

Huss-Marp, J; Darsow, U; Brockow, K; Pfab, F; Weichenmeier, I; Schober, W; Petersson, CJ; Borres, MP; Ring, J; Behrendt, H

doi:10.1111/j.1365-2222.2011.03745.x

2011

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Document type:: Journal Article; Article
Author(s):: Huss-Marp, J; Darsow, U; Brockow, K; Pfab, F; Weichenmeier, I; Schober, W; Petersson, CJ; Borres, MP; Ring, J; Behrendt, H
Title:: Can Immunoglobulin E-measurement replace challenge tests in allergic rhinoconjunctivits to grass pollen?
Abstract:: There is minimal data available concerning the dose-response relationship between allergen exposure and clinical reactivity for outdoor aeroallergens, such as timothy grass pollen. Timothy pollen-specific IgE (sIgE) determinations might assist in predicting the clinical reactivity in patients with allergic rhinoconjunctivitis (ARC).Allergen-sIgE antibody levels of timothy grass pollen were correlated with individual threshold doses eliciting allergic reactions in skin prick test (SPT), conjunctival (CPT) and nasal (NPT) provocation tests in patients suffering from pollen-induced rhinoconjunctivitis and healthy controls.One hundred and four patients with ARC (median age: 27 years; range: 18-64; females: 58%) and 36 controls (25 years (22-77); females: 70%) were included in the study. Ninety-six percent of the patients showed a positive reaction in the nasal and 57% showed a positive reaction in the conjunctival provocation. With regarding to titrated SPT, 98% of the patients showed a positive skin test reaction; correlating with the level of sIgE for timothy (P < 0.001). For both provocation protocols, there was no correlation between the provocation concentration at the reaction and the level of sIgE for timothy. The ratio of sIgE/total IgE correlated with the dilution level of SPT (P < 0.002) and CPT (P < 0.01), respectively.A dose-response relationship between the levels of sIgE and clinical outcome of timothy allergen exposure could not be established. Although IgE-determination remains an important key element in allergy diagnosis, provocation tests are procedures of choice if the clinical relevance of an allergen has to be confirmed.
Journal title abbreviation:: Clin Exp Allergy
Year:: 2011
Journal volume:: 41
Journal issue:: 8
Pages contribution:: 1116-24
Language:: eng
Fulltext / DOI:: doi:10.1111/j.1365-2222.2011.03745.x
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/21518042
Print-ISSN:: 0954-7894
TUM Institution:: Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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