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Title:

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Lückerath, K; Kirkin, V; Melzer, IM; Thalheimer, FB; Siele, D; Milani, W; Adler, T; Aguilar-Pimentel, A; Horsch, M; Michel, G; Beckers, J; Busch, DH; Ollert, M; Gailus-Durner, V; Fuchs, H; Hrabé de Angelis, M; Staal, FJ; Rajalingam, K; Hueber, AO; Strobl, LJ; Zimber-Strobl, U; Zörnig, M
Abstract:
Fas ligand (FasL) not only induces apoptosis in Fas receptor-bearing target cells, it is also able to transmit signals into the FasL-expressing cell via its intracellular domain (ICD). Recently, we described a Notch-like proteolytic processing of FasL that leads to the release of the FasL ICD into the cytoplasm and subsequent translocation into the nucleus where it may influence gene transcription. To study the molecular mechanism underlying such reverse FasL signaling in detail and to analyze i...     »
Journal title abbreviation:
Blood
Year:
2011
Journal volume:
117
Journal issue:
2
Pages contribution:
519-29
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2010-07-292722
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20971954
Print-ISSN:
0006-4971
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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