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Title:

Xenon Enhances LPS-Induced IL-1? Expression in Microglia via the Extracellular Signal-Regulated Kinase 1/2 Pathway.

Document type:
Journal Article
Author(s):
Fahlenkamp, AV; Coburn, M; Haase, H; Kipp, M; Ryang, YM; Rossaint, R; Beyer, C
Abstract:
The extracellular signal-regulated kinase (ERK) is involved in the cytokine production of immune cells. In this study, we show the influence of xenon on phosphatase activity, ERK 1/2 signalling and cytokine expression in microglia. The murine microglia cell line BV-2 was treated with 50 ng/ml lipopolysaccharide (LPS) and 74% xenon in 21% O(2) and 5% CO(2). Cytokine levels were examined by gene expression analysis, Western blot and enzyme-linked immunosorbent assay. Phosphatase inhibition was ass...     »
Journal title abbreviation:
J Mol Neurosci
Year:
2011
Journal volume:
45
Journal issue:
1
Pages contribution:
48-59
Language:
eng
Fulltext / DOI:
doi:10.1007/s12031-010-9432-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20680516
Print-ISSN:
0895-8696
TUM Institution:
Neurochirurgische Klinik und Poliklinik
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