Stereotactic fractionated radiotherapy and LINAC radiosurgery in the treatment of vestibular schwannoma-report about both stereotactic methods from a single institution.

Kopp, C; Fauser, C; Müller, A; Astner, ST; Jacob, V; Lumenta, C; Meyer, B; Tonn, JC; Molls, M; Grosu, AL

doi:10.1016/j.ijrobp.2010.04.057

2011

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Title:: Stereotactic fractionated radiotherapy and LINAC radiosurgery in the treatment of vestibular schwannoma-report about both stereotactic methods from a single institution.
Document type:: Journal Article
Author(s):: Kopp, C; Fauser, C; Müller, A; Astner, ST; Jacob, V; Lumenta, C; Meyer, B; Tonn, JC; Molls, M; Grosu, AL
Abstract:: To evaluate tumor control and side effects associated with radiosurgery (RS) and stereotactic fractionated radiotherapy (SFR) for vestibular schwannomas (VSs) in a group of patients treated at the same institution.Between May 1997 and June 2007, 115 consecutive cases of VS were treated in our department. The SFR group (47 patients), including larger tumors (maximum diameter >1.5 cm), received a total dose of 54 Gy at 1.8 Gy per fraction. The RS group (68 patients, maximum diameter <1.5 cm) received a total dose of 12 Gy at the 100% isodose. Evaluation included serial imaging tests (magnetic resonance imaging) and neurologic and functional hearing examinations.The tumor control rate was 97.9% in the SFR group for a mean follow-up time of 32.1 months and 98.5% in the RS group for a mean follow-up time of 30.1 months. Hearing function was preserved after RS in 85% of the patients and after SFR in 79%. Facial and trigeminal nerve function remained mostly unaffected after SFR. After RS, new trigeminal neuropathy occurred in 9 of 68 patients (13%).A high tumor control rate and low number of side effects are registered after SFR and RS of VS. These results confirm that considering tumor diameter, both RS and SFR are good treatment modalities for VS.
Journal title abbreviation:: Int J Radiat Oncol Biol Phys
Year:: 2011
Journal volume:: 80
Journal issue:: 5
Pages contribution:: 1485-91
Language:: eng
Fulltext / DOI:: doi:10.1016/j.ijrobp.2010.04.057
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/20708852
Print-ISSN:: 0360-3016
TUM Institution:: Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Neurochirurgische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurochirurgie (Prof. Meyer)2011

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)2011