Benutzer: Gast  Login
Titel:

HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Matt, L; Michalakis, S; Hofmann, F; Hammelmann, V; Ludwig, A; Biel, M; Kleppisch, T
Abstract:
Neuronal hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are known to modulate spontaneous activity, resting membrane potential, input resistance, afterpotential, rebound activity, and dendritic integration. To evaluate the role of HCN2 for hippocampal synaptic plasticity, we recorded long-term potentiation (LTP) in the direct perforant path (PP) to CA1 pyramidal cells. LTP was enhanced in mice carrying a global deletion of the channel (HCN2(-/-)) but not in a pyramidal neuron...     »
Zeitschriftentitel:
Cell Mol Life Sci
Jahr:
2011
Band / Volume:
68
Heft / Issue:
1
Seitenangaben Beitrag:
125-37
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00018-010-0446-z
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20623157
Print-ISSN:
1420-682X
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
 BibTeX