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Title:

Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Michalakis, S; Kleppisch, T; Polta, SA; Wotjak, CT; Koch, S; Rammes, G; Matt, L; Becirovic, E; Biel, M
Abstract:
The role of the cyclic nucleotide-gated (CNG) channel CNGA3 is well established in cone photoreceptors and guanylyl cyclase-D-expressing olfactory neurons. To assess a potential function of CNGA3 in the mouse amygdala and hippocampus, we examined synaptic plasticity and performed a comparative analysis of spatial learning, fear conditioning and step-down avoidance in wild-type mice and CNGA3 null mutants (CNGA3(-/-) ). CNGA3(-/-) mice showed normal basal synaptic transmission in the amygdala and...     »
Journal title abbreviation:
Genes Brain Behav
Year:
2011
Journal volume:
10
Journal issue:
2
Pages contribution:
137-48
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1601-183X.2010.00646.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20846178
Print-ISSN:
1601-1848
TUM Institution:
Institut für Pharmakologie und Toxikologie; Klinik für Anästhesiologie (DHM)
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