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Title:

Cyclic GMP kinase I modulates glucagon release from pancreatic ?-cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Leiss, V; Friebe, A; Welling, A; Hofmann, F; Lukowski, R
Abstract:
The physiologic significance of the nitric oxide (NO)/cGMP signaling pathway in islets is unclear. We hypothesized that cGMP-dependent protein kinase type I (cGKI) is directly involved in the secretion of islet hormones and glucose homeostasis.Gene-targeted mice that lack cGKI in islets (conventional cGKI mutants and cGKI? and I? rescue mice [?/?RM] that express cGKI only in smooth muscle) were studied in comparison to control (CTR) mice. cGKI expression was mapped in the endocrine pancreas by W...     »
Journal title abbreviation:
Diabetes
Year:
2011
Journal volume:
60
Journal issue:
1
Pages contribution:
148-56
Language:
eng
Fulltext / DOI:
doi:10.2337/db10-0595
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20978093
Print-ISSN:
0012-1797
TUM Institution:
Institut für Pharmakologie und Toxikologie
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