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Title:

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Moretti, A; Bellin, M; Jung, CB; Thies, TM; Takashima, Y; Bernshausen, A; Schiemann, M; Fischer, S; Moosmang, S; Smith, AG; Lam, JT; Laugwitz, KL
Abstract:
Ectopic expression of defined sets of genetic factors can reprogram somatic cells to create induced pluripotent stem (iPS) cells. The capacity to direct human iPS cells to specific differentiated lineages and to their progenitor populations can be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. During mouse cardiogenesis, the major lineages of the mature heart, cardiomyocytes, smooth muscle cells, and endothelial cells arise from a common, multipo...     »
Journal title abbreviation:
FASEB J
Year:
2010
Journal volume:
24
Journal issue:
3
Pages contribution:
700-11
Language:
eng
Fulltext / DOI:
doi:10.1096/fj.09-139477
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19850773
Print-ISSN:
0892-6638
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Pharmakologie und Toxikologie
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