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Title:

Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet
Author(s):
von Figura, G; Wagner, M; Nalapareddy, K; Hartmann, D; Kleger, A; Guachalla, LM; Rolyan, H; Adler, G; Rudolph, KL
Abstract:
Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that accelerate cell turnover, such as chronic hepatitis. Telomere shortening can limit organ homeostasis and regeneration in response to injury. Whether the same holds true for pancreas regeneration in response to injury is not known.In...     »
Journal title abbreviation:
PLoS ONE
Year:
2011
Journal volume:
6
Journal issue:
2
Pages contribution:
e17122
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0017122
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21364961
Print-ISSN:
1932-6203
TUM Institution:
Chirurgische Klinik und Poliklinik
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