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Document type:
Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet 
Author(s):
von Figura, G; Wagner, M; Nalapareddy, K; Hartmann, D; Kleger, A; Guachalla, LM; Rolyan, H; Adler, G; Rudolph, KL 
Title:
Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice. 
Abstract:
Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that accelerate cell turnover, such as chronic hepatitis. Telomere shortening can limit organ homeostasis and regeneration in response to injury. Whether the same holds true for pancreas regeneration in response to injury is not known.In...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2011 
Journal volume:
Journal issue:
Pages contribution:
e17122 
Language:
eng 
Print-ISSN:
1932-6203 
TUM Institution:
Chirurgische Klinik und Poliklinik