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Title:

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

Document type:
Journal Article; Article
Author(s):
Lucifora, J; Arzberger, S; Durantel, D; Belloni, L; Strubin, M; Levrero, M; Zoulim, F; Hantz, O; Protzer, U
Abstract:
The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.Primary human hepatocytes and differentiated HepaRG cells allowing conditional trans complementation of HBx were infected with wild type (HBV(wt)) or HBx deficient (HBV(x-)) HBV particles and establishment of HBV replication was followed.We observed that cells inoculated with HBx-deficient HBV particles (HBV(x...     »
Journal title abbreviation:
J Hepatol
Year:
2011
Journal volume:
55
Journal issue:
5
Pages contribution:
996-1003
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jhep.2011.02.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21376091
Print-ISSN:
0168-8278
TUM Institution:
Institut für Virologie
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