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Titel:

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

Dokumenttyp:
Journal Article; Article
Autor(en):
Lucifora, J; Arzberger, S; Durantel, D; Belloni, L; Strubin, M; Levrero, M; Zoulim, F; Hantz, O; Protzer, U
Abstract:
The molecular biology of hepatitis B virus (HBV) has been extensively studied but the exact role of the hepatitis B X protein (HBx) in the context of natural HBV infections remains unknown.Primary human hepatocytes and differentiated HepaRG cells allowing conditional trans complementation of HBx were infected with wild type (HBV(wt)) or HBx deficient (HBV(x-)) HBV particles and establishment of HBV replication was followed.We observed that cells inoculated with HBx-deficient HBV particles (HBV(x...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2011
Band / Volume:
55
Heft / Issue:
5
Seitenangaben Beitrag:
996-1003
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jhep.2011.02.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21376091
Print-ISSN:
0168-8278
TUM Einrichtung:
Institut für Virologie
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