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Title:

Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B.

Document type:
Journal Article
Author(s):
von Freyend, MJ; Untergasser, A; Arzberger, S; Oberwinkler, H; Drebber, U; Schirmacher, P; Protzer, U
Abstract:
The determinants of an immune response to the human hepatitis B virus (HBV) are poorly understood. As studies in man and chimpanzees are limited, we aimed at developing a model of self-limiting hepatitis B in mice that helps to dissect the control of HBV by humoral and cellular immune responses. Adenoviral vectors containing 1.3-fold HBV genomes allowed an efficient and reproducible transfer of HBV genomes into mouse livers and initiated HBV replication in mice. HBV transcripts were detected in...     »
Journal title abbreviation:
J Viral Hepat
Year:
2011
Journal volume:
18
Journal issue:
3
Pages contribution:
216-26
Language:
eng
Fulltext / DOI:
doi:10.1111/j.1365-2893.2010.01302.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20367794
Print-ISSN:
1352-0504
TUM Institution:
Institut für Virologie
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