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Title:

Aerosols transmit prions to immunocompetent and immunodeficient mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Haybaeck, J; Heikenwalder, M; Klevenz, B; Schwarz, P; Margalith, I; Bridel, C; Mertz, K; Zirdum, E; Petsch, B; Fuchs, TJ; Stitz, L; Aguzzi, A
Abstract:
Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 transgenic mice overexpressing PrP(C), efficiently develop scrapie upon exposure to aerosolized prions. NSE-PrP transgenic mice, which express PrP(C) selectively in neurons, were also susceptible to ai...     »
Journal title abbreviation:
PLoS Pathog
Year:
2011
Journal volume:
7
Journal issue:
1
Pages contribution:
e1001257
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.1001257
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21249178
Print-ISSN:
1553-7366
TUM Institution:
Institut für Virologie
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