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Title:

Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Siegert, S; Huang, HY; Yang, CY; Scarpellino, L; Carrie, L; Essex, S; Nelson, PJ; Heikenwalder, M; Acha-Orbea, H; Buckley, CD; Marsland, BJ; Zehn, D; Luther, SA
Abstract:
Adaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that FRC lines and ex vivo FRC inhibit T cell proliferation but not differentiation. FRC share this feature with fibroblasts from non-lymphoid tissues as well as mesenchymal stromal cells. We identified FR...     »
Journal title abbreviation:
PLoS ONE
Year:
2011
Journal volume:
6
Journal issue:
11
Pages contribution:
e27618
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0027618
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22110693
Print-ISSN:
1932-6203
TUM Institution:
Institut für Virologie
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