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Titel:

Aerosols transmit prions to immunocompetent and immunodeficient mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Haybaeck, J; Heikenwalder, M; Klevenz, B; Schwarz, P; Margalith, I; Bridel, C; Mertz, K; Zirdum, E; Petsch, B; Fuchs, TJ; Stitz, L; Aguzzi, A
Abstract:
Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne. Here we report that inbred and crossbred wild-type mice, as well as tga20 transgenic mice overexpressing PrP(C), efficiently develop scrapie upon exposure to aerosolized prions. NSE-PrP transgenic mice, which express PrP(C) selectively in neurons, were also susceptible to ai...     »
Zeitschriftentitel:
PLoS Pathog
Jahr:
2011
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
e1001257
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.ppat.1001257
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21249178
Print-ISSN:
1553-7366
TUM Einrichtung:
Institut für Virologie
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