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Titel:

Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Friedrich, L; Stangl, S; Hahne, H; Küster, B; Köhler, P; Multhoff, G; Skerra, A
Abstract:
Hsp70, the major stress-inducible member of the 70 kDa heat shock protein family, is frequently exposed on the plasma membrane of human tumours and, even more pronounced, on metastases but not detectable on normal tissues. The mouse monoclonal antibody cmHsp70.1, which recognizes a peptide epitope in the C-terminal substrate binding domain of both human and murine Hsp70, provides a promising reagent for the monitoring of Hsp70-positive tumours during cancer therapy. Here, we describe the variabl...     »
Zeitschriftentitel:
Protein Eng Des Sel
Jahr:
2010
Band / Volume:
23
Heft / Issue:
4
Seitenangaben Beitrag:
161-8
Sprache:
eng
Volltext / DOI:
doi:10.1093/protein/gzp095
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20123884
Print-ISSN:
1741-0126
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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