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Title:

Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Reimann, M; Lee, S; Loddenkemper, C; Dörr, JR; Tabor, V; Aichele, P; Stein, H; Dörken, B; Jenuwein, T; Schmitt, CA
Abstract:
Activated RAS/BRAF oncogenes induce cellular senescence as a tumor-suppressive barrier in early cancer development, at least in part, via an oncogene-evoked DNA damage response (DDR). In contrast, Myc activation-although producing a DDR as well-is known to primarily elicit an apoptotic countermeasure. Using the Emu-myc transgenic mouse lymphoma model, we show here in vivo that apoptotic lymphoma cells activate macrophages to secrete transforming growth factor beta (TGF-beta) as a critical non-ce...     »
Journal title abbreviation:
Cancer Cell
Year:
2010
Journal volume:
17
Journal issue:
3
Pages contribution:
262-72
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ccr.2009.12.043
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20227040
Print-ISSN:
1535-6108
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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