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Titel:

MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays.

Dokumenttyp:
Journal Article
Autor(en):
Kutscher, S; Allgayer, S; Dembek, CJ; Bogner, JR; Protzer, U; Goebel, FD; Erfle, V; Cosma, A
Abstract:
Several vaccination trials are evaluating the modified vaccinia virus Ankara (MVA) as a delivery vector in various clinical settings. In this paper, we present the reevaluation of a therapeutic vaccination trial in human immunodeficiency virus (HIV)-1-infected individuals treated with highly active antiretroviral therapy using MVA-expressing HIV-1 nef. Immunogenicity of MVA-nef was assessed using multicolor flow cytometry. Vaccine-induced polyfunctionality and proliferative capacity, which are a...     »
Zeitschriftentitel:
Gene Ther
Jahr:
2010
Band / Volume:
17
Heft / Issue:
11
Seitenangaben Beitrag:
1372-83
Sprache:
eng
Volltext / DOI:
doi:10.1038/gt.2010.90
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20535218
Print-ISSN:
0969-7128
TUM Einrichtung:
Institut für Virologie
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