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Title:

GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Kimura, T; Ishikawa, K; Sakasegawa, Y; Teruya, K; Sata, T; Schätzl, H; Doh-ura, K
Abstract:
Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. Silencing of gabrb1 gene expression significantly decreased the abnormal prion protein level but paradoxically increased the normal prion protein level. Treatment with a gabrb1-specific inhibitor, salicylidene salicylhydrazide, dose-depe...     »
Journal title abbreviation:
FEBS Lett
Year:
2010
Journal volume:
584
Journal issue:
6
Pages contribution:
1193-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.febslet.2010.02.029
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20159020
Print-ISSN:
0014-5793
TUM Institution:
Institut für Virologie
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