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Title:

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Bailly-Maitre, B; Belgardt, BF; Jordan, SD; Coornaert, B; von Freyend, MJ; Kleinridders, A; Mauer, J; Cuddy, M; Kress, CL; Willmes, D; Essig, M; Hampel, B; Protzer, U; Reed, JC; Brüning, JC
Abstract:
The unfolded protein response (UPR) or endoplasmic reticulum (ER) stress response is a physiological process enabling cells to cope with altered protein synthesis demands. However, under conditions of obesity, prolonged activation of the UPR has been shown to have deteriorating effects on different metabolic pathways. Here we identify Bax inhibitor-1 (BI-1), an evolutionary conserved ER-membrane protein, as a novel modulator of the obesity-associated alteration of the UPR. BI-1 partially inhibit...     »
Journal title abbreviation:
J Biol Chem
Year:
2010
Journal volume:
285
Journal issue:
9
Pages contribution:
6198-207
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M109.056648
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19996103
Print-ISSN:
0021-9258
TUM Institution:
Institut für Virologie
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