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Titel:

GABAA receptor subunit beta1 is involved in the formation of protease-resistant prion protein in prion-infected neuroblastoma cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Kimura, T; Ishikawa, K; Sakasegawa, Y; Teruya, K; Sata, T; Schätzl, H; Doh-ura, K
Abstract:
Gamma-aminobutyric acid type A (GABAA) receptor beta1 (gabrb1), a subunit of GABAA receptors involved in inhibitory effects on neurotransmission, was found to associate with the formation of protease-resistant prion protein in prion-infected neuroblastoma cells. Silencing of gabrb1 gene expression significantly decreased the abnormal prion protein level but paradoxically increased the normal prion protein level. Treatment with a gabrb1-specific inhibitor, salicylidene salicylhydrazide, dose-depe...     »
Zeitschriftentitel:
FEBS Lett
Jahr:
2010
Band / Volume:
584
Heft / Issue:
6
Seitenangaben Beitrag:
1193-8
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.febslet.2010.02.029
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20159020
Print-ISSN:
0014-5793
TUM Einrichtung:
Institut für Virologie
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