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Titel:

Bioluminescence imaging allows measuring CD8 T cell function in the liver.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Autor(en):
Stabenow, D; Frings, M; Trück, C; Gärtner, K; Förster, I; Kurts, C; Tüting, T; Odenthal, M; Dienes, HP; Cederbrant, K; Protzer, U; Knolle, PA
Abstract:
In vivo evaluation of CD8 T cell effector (cytotoxic T lymphocyte [CTL]) function in peripheral organs such as the liver is currently not possible but would greatly improve our understanding of local immune regulation, because simple determination of antigen-specific CTL numbers does not predict the outcome of immune responses. In particular, measurement of alanine aminotransferase serum levels is not sensitive enough to detect T cell immunity against low numbers of target hepatocytes. We develo...     »
Zeitschriftentitel:
Hepatology
Jahr:
2010
Band / Volume:
51
Heft / Issue:
4
Seitenangaben Beitrag:
1430-7
Sprache:
eng
Volltext / DOI:
doi:10.1002/hep.23575
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20373369
Print-ISSN:
0270-9139
TUM Einrichtung:
Institut für Virologie
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