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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Roffé, M; Beraldo, FH; Bester, R; Nunziante, M; Bach, C; Mancini, G; Gilch, S; Vorberg, I; Castilho, BA; Martins, VR; Hajj, GN
Titel:
Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Abstract:
Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused by the conversion of prion protein (PrP(C)) into an infectious isoform (PrP(Sc)). How this event leads to pathology is not fully understood. Here we demonstrate that protein synthesis in neurons is enhanced via PrP(C) interaction with stress-inducible protein 1 (STI1). We also show that neuroprotection and neuritogenesis mediated by PrP(C)-STI1 engagement are dependent upon the increased protein synthesis media...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2010
Band / Volume:
107
Heft / Issue:
29
Seitenangaben Beitrag:
13147-52
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1000784107
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20615969
Print-ISSN:
0027-8424
TUM Einrichtung:
Institut für Virologie
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