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Titel:

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase C?2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model.

Dokumenttyp:
Journal Article
Autor(en):
Abe, K; Fuchs, H; Boersma, A; Hans, W; Yu, P; Kalaydjiev, S; Klaften, M; Adler, T; Calzada-Wack, J; Mossbrugger, I; Rathkolb, B; Rozman, J; Prehn, C; Maraslioglu, M; Kametani, Y; Shimada, S; Adamski, J; Busch, DH; Esposito, I; Klingenspor, M; Wolf, E; Wurst, W; Gailus-Durner, V; Katan, M; Marschall, S; Soewarto, D; Wagner, S; de Angelis, MH
Abstract:
It is difficult to identify a single causative factor for inflammatory arthritis because of the multifactorial nature of the disease. This study was undertaken to dissect the molecular complexity of systemic inflammatory disease, utilizing a combined approach of mutagenesis and systematic phenotype screening in a murine model.In a large-scale N-ethyl-N-nitrosourea mutagenesis project, the Ali14 mutant mouse strain was established because of dominant inheritance of spontaneous swelling and inflam...     »
Zeitschriftentitel:
Arthritis Rheum
Jahr:
2011
Band / Volume:
63
Heft / Issue:
5
Seitenangaben Beitrag:
1301-11
Sprache:
eng
Volltext / DOI:
doi:10.1002/art.30280
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21305534
Print-ISSN:
0004-3591
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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