Benutzer: Gast  Login
Titel:

Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation.

Dokumenttyp:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't; nicht gelistet
Autor(en):
Schmitt, A; Tonn, T; Busch, DH; Grigoleit, GU; Einsele, H; Odendahl, M; Germeroth, L; Ringhoffer, M; Ringhoffer, S; Wiesneth, M; Greiner, J; Michel, D; Mertens, T; Rojewski, M; Marx, M; von Harsdorf, S; Döhner, H; Seifried, E; Bunjes, D; Schmitt, M
Abstract:
Cytomegalovirus (CMV) disease constitutes a serious complication after allogeneic stem cell transplantation. For the clearance of CMV, CD8+ T cells are pivotal.Here, the novel streptamer technology was used at good manufacturing practice (GMP) level for adoptive transfer of CMV-specific T cells into acute leukemia patients with recurrent high CMV antigenemia after allogeneic stem cell transplantation.After a single transfusion, the frequency of CMV-specific CD8+CD45RA+CCR7- effector T cells incr...     »
Zeitschriftentitel:
Transfusion
Jahr:
2011
Band / Volume:
51
Heft / Issue:
3
Seitenangaben Beitrag:
591-9
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1537-2995.2010.02940.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21133926
Print-ISSN:
0041-1132
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX