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Title:

CCL17 controls mast cells for the defense against filarial larval entry.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Specht, S; Frank, JK; Alferink, J; Dubben, B; Layland, LE; Denece, G; Bain, O; Förster, I; Kirschning, CJ; Martin, C; Hoerauf, A
Abstract:
Filarial parasites have to trespass many barriers to successfully settle within their mammalian host, which is equipped with mechanical borders and complex weaponry of an evolved immune system. However, little is known about mechanisms of early local events in filarial infections. In this study, bone marrow-derived dendritic cells not only upregulated activation markers CD40 and CD80 upon in vitro stimulation with filarial extracts, but also secreted CCL17, a chemokine known to be produced upon...     »
Journal title abbreviation:
J Immunol
Year:
2011
Journal volume:
186
Journal issue:
8
Pages contribution:
4845-52
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1000612
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21398605
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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