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Titel:

Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Lückerath, K; Kirkin, V; Melzer, IM; Thalheimer, FB; Siele, D; Milani, W; Adler, T; Aguilar-Pimentel, A; Horsch, M; Michel, G; Beckers, J; Busch, DH; Ollert, M; Gailus-Durner, V; Fuchs, H; Hrabé de Angelis, M; Staal, FJ; Rajalingam, K; Hueber, AO; Strobl, LJ; Zimber-Strobl, U; Zörnig, M
Abstract:
Fas ligand (FasL) not only induces apoptosis in Fas receptor-bearing target cells, it is also able to transmit signals into the FasL-expressing cell via its intracellular domain (ICD). Recently, we described a Notch-like proteolytic processing of FasL that leads to the release of the FasL ICD into the cytoplasm and subsequent translocation into the nucleus where it may influence gene transcription. To study the molecular mechanism underlying such reverse FasL signaling in detail and to analyze i...     »
Zeitschriftentitel:
Blood
Jahr:
2011
Band / Volume:
117
Heft / Issue:
2
Seitenangaben Beitrag:
519-29
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2010-07-292722
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20971954
Print-ISSN:
0006-4971
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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