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Title:

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hoegen, T; Tremel, N; Klein, M; Angele, B; Wagner, H; Kirschning, C; Pfister, HW; Fontana, A; Hammerschmidt, S; Koedel, U
Abstract:
Streptococcus pneumoniae meningitis causes brain damage through inflammation-related pathways whose identity and mechanisms of action are yet unclear. We previously identified caspase-1, which activates precursor IL-1 type cytokines, as a central mediator of inflammation in pneumococcal meningitis. In this study, we demonstrate that lack of the inflammasome components ASC or NLRP3 that are centrally involved in caspase-1 activation decreases scores of clinical and histological disease severity a...     »
Journal title abbreviation:
J Immunol
Year:
2011
Journal volume:
187
Journal issue:
10
Pages contribution:
5440-51
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1100790
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22003197
Print-ISSN:
0022-1767
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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