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Titel:

CCL17 controls mast cells for the defense against filarial larval entry.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Specht, S; Frank, JK; Alferink, J; Dubben, B; Layland, LE; Denece, G; Bain, O; Förster, I; Kirschning, CJ; Martin, C; Hoerauf, A
Abstract:
Filarial parasites have to trespass many barriers to successfully settle within their mammalian host, which is equipped with mechanical borders and complex weaponry of an evolved immune system. However, little is known about mechanisms of early local events in filarial infections. In this study, bone marrow-derived dendritic cells not only upregulated activation markers CD40 and CD80 upon in vitro stimulation with filarial extracts, but also secreted CCL17, a chemokine known to be produced upon...     »
Zeitschriftentitel:
J Immunol
Jahr:
2011
Band / Volume:
186
Heft / Issue:
8
Seitenangaben Beitrag:
4845-52
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1000612
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21398605
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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