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Title:

Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome.

Document type:
Journal Article; Article
Author(s):
Laika, B; Leucht, S; Heres, S; Schneider, H; Steimer, W
Abstract:
Psychiatric pharmacotherapy with olanzapine is commonplace. We investigated the influence of CYP1A2*1F (-163A, rs762551) and serotonergic polymorphisms on olanzapine serum concentrations and clinical outcome in a naturalistic clinical setting. Included were 124 Caucasian psychiatric inpatients treated with olanzapine for at least 4 weeks with steady-state serum concentrations available for 73 patients. The CYP1A2*1F polymorphism was reported to affect the inducibility of CYP1A2. In our study pop...     »
Journal title abbreviation:
Pharmacogenomics J
Year:
2010
Journal volume:
10
Journal issue:
1
Pages contribution:
20-9
Language:
eng
Fulltext / DOI:
doi:10.1038/tpj.2009.32
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19636338
Print-ISSN:
1470-269X
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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