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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
Author(s):
Yang, S; Wang, X; Contino, G; Liesa, M; Sahin, E; Ying, H; Bause, A; Li, Y; Stommel, JM; Dell'antonio, G; Mautner, J; Tonon, G; Haigis, M; Shirihai, OS; Doglioni, C; Bardeesy, N; Kimmelman, AC 
Title:
Pancreatic cancers require autophagy for tumor growth. 
Abstract:
Macroautophagy (autophagy) is a regulated catabolic pathway to degrade cellular organelles and macromolecules. The role of autophagy in cancer is complex and may differ depending on tumor type or context. Here we show that pancreatic cancers have a distinct dependence on autophagy. Pancreatic cancer primary tumors and cell lines show elevated autophagy under basal conditions. Genetic or pharmacologic inhibition of autophagy leads to increased reactive oxygen species, elevated DNA damage, and a m...    »
 
Journal title abbreviation:
Genes Dev 
Year:
2011 
Journal volume:
25 
Journal issue:
Pages contribution:
717-29 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0890-9369 
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin