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Document type:
Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Keymeulen, B; Candon, S; Fafi-Kremer, S; Ziegler, A; Leruez-Ville, M; Mathieu, C; Vandemeulebroucke, E; Walter, M; Crenier, L; Thervet, E; Legendre, C; Pierard, D; Hale, G; Waldmann, H; Bach, JF; Seigneurin, JM; Pipeleers, D; Chatenoud, L 
Title:
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. 
Abstract:
Here we report a unique situation in which an early and synchronized Epstein-Barr virus (EBV) reactivation was induced by a 6-day course of treatment with a humanized CD3-specific monoclonal antibody in patients with recent onset of type 1 diabetes. The virologic and immunologic analysis demonstrated that this reactivation was transient, self-limited, and isolated, associated with the rapid advent of an EBV-specific T-cell response. The anti-CD3 antibody administration induced short-lasting immu...    »
 
Journal title abbreviation:
Blood 
Year:
2010 
Journal volume:
115 
Journal issue:
Pages contribution:
1145-55 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin