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Document type:
Journal Article; Research Support, N.I.H., Extramural; Review; Review 
Author(s):
Ziegler, AG; Nepom, GT 
Title:
Prediction and pathogenesis in type 1 diabetes. 
Abstract:
A combination of genetic and immunological features is useful for prediction of autoimmune diabetes. Patterns of immune response correspond to the progression from a preclinical phase of disease to end-stage islet damage, with biomarkers indicating transition from susceptibility to active autoimmunity, and to a final loss of immune regulation. Here, we review the markers that provide evidence for immunological checkpoint failure and that also provide tools for assessment of individualized diseas...    »
 
Journal title abbreviation:
Immunity 
Year:
2010 
Journal volume:
32 
Journal issue:
Pages contribution:
468-78 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin