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Titel:

Solubility prediction of drugs in mixed solvents using partial solubility parameters.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Jouyban, A; Shayanfar, A; Panahi-Azar, V; Soleymani, J; Yousefi, BH; Acree, WE; York, P
Abstract:
Solubility of drugs in binary and ternary solvent mixtures composed of water and pharmaceutical cosolvents at different temperatures were predicted using the Jouyban-Acree model and a combination of partial solubility parameters as interaction descriptors in the solution. The generally trained version of the model produced the overall mean percentage deviation values for the back-calculated solubility of drugs in binary solvents of 34.3% and the predicted solubilities in ternary solvent mixtures...     »
Zeitschriftentitel:
J Pharm Sci
Jahr:
2011
Band / Volume:
100
Heft / Issue:
10
Seitenangaben Beitrag:
4368-82
Sprache:
eng
Volltext / DOI:
doi:10.1002/jps.22589
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21630276
Print-ISSN:
0022-3549
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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