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Title:

Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Halama, N; Michel, S; Kloor, M; Zoernig, I; Benner, A; Spille, A; Pommerencke, T; von Knebel, DM; Folprecht, G; Luber, B; Feyen, N; Martens, UM; Beckhove, P; Gnjatic, S; Schirmacher, P; Herpel, E; Weitz, J; Grabe, N; Jaeger, D
Abstract:
Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer (CRC) by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human CRC. Specifically, high densities of TILs in the primary tumor are associated with good prognosis independent of other prognostic markers. However, the prognostic role of TILs in metastatic CRC lesions is unknown, as is their role in response or resistance to conventional chemothe...     »
Journal title abbreviation:
Cancer Res
Year:
2011
Journal volume:
71
Journal issue:
17
Pages contribution:
5670-7
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-11-0268
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21846824
Print-ISSN:
0008-5472
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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