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Title:

Imaging of intact tissue sections: moving beyond the microscope.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
Author(s):
Seeley, EH; Schwamborn, K; Caprioli, RM
Abstract:
MALDI-imaging MS is a new molecular imaging technology for direct in situ analysis of thin tissue sections. Multiple analytes can be monitored simultaneously without prior knowledge of their identities and without the need for target-specific reagents such as antibodies. Imaging MS provides important insights into biological processes because the native distributions of molecules are minimally disturbed, and histological features remain intact throughout the analysis. A wide variety of molecules...     »
Journal title abbreviation:
J Biol Chem
Year:
2011
Journal volume:
286
Journal issue:
29
Pages contribution:
25459-66
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.R111.225854
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21632549
Print-ISSN:
0021-9258
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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