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Title:

Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Herner, A; Sauliunaite, D; Michalski, CW; Erkan, M; De Oliveira, T; Abiatari, I; Kong, B; Esposito, I; Friess, H; Kleeff, J
Abstract:
Glutamate has been implicated in tumorigenesis through activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR). However, the function of a glutamate-to-AMPAR signal in pancreatic ductal adenocarcinoma (PDAC) has remained elusive. We now show that glutamate-mediated AMPA receptor activation increases invasion and migration of pancreatic cancer cells via activation of the classical MAPK pathway. Glutamate levels were increased in pancreatic cancer accompanie...     »
Journal title abbreviation:
Int J Cancer
Year:
2011
Journal volume:
129
Journal issue:
10
Pages contribution:
2349-59
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.25898
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21207374
Print-ISSN:
0020-7136
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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