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Titel:

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Chalmin, F; Ladoire, S; Mignot, G; Vincent, J; Bruchard, M; Remy-Martin, JP; Boireau, W; Rouleau, A; Simon, B; Lanneau, D; De Thonel, A; Multhoff, G; Hamman, A; Martin, F; Chauffert, B; Solary, E; Zitvogel, L; Garrido, C; Ryffel, B; Borg, C; Apetoh, L; Rébé, C; Ghiringhelli, F
Abstract:
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans and have been shown to contribute to cancer development. Here, we have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and MDSCs determines the suppressive activity of the MDSCs via activation of Stat3. In ad...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2010
Band / Volume:
120
Heft / Issue:
2
Seitenangaben Beitrag:
457-71
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI40483
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20093776
Print-ISSN:
0021-9738
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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