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Titel:

Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle?

Dokumenttyp:
Journal Article; Review
Autor(en):
Otto, S; Hafner, S; Mast, G; Tischer, T; Volkmer, E; Schieker, M; Stürzenbaum, SR; von Tresckow, E; Kolk, A; Ehrenfeld, M; Pautke, C
Abstract:
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphosphonate therapy, primarily diagnosed in patients with cancer and metastatic bone disease and receiving intravenous administrations of nitrogen-containing bisphosphonates. If diagnosis or treatment is delayed, BRONJ can develop to a severe and devastating disease. Numerous studies have focused on BRONJ, with possible pathomechanisms identified to be oversuppression of bone turnover, ischemia due to antiangiogenetic...     »
Zeitschriftentitel:
J Oral Maxillofac Surg
Jahr:
2010
Band / Volume:
68
Heft / Issue:
5
Seitenangaben Beitrag:
1158-61
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.joms.2009.07.079
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20138420
Print-ISSN:
0278-2391
TUM Einrichtung:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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