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Title:

Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle?

Document type:
Journal Article; Review
Author(s):
Otto, S; Hafner, S; Mast, G; Tischer, T; Volkmer, E; Schieker, M; Stürzenbaum, SR; von Tresckow, E; Kolk, A; Ehrenfeld, M; Pautke, C
Abstract:
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphosphonate therapy, primarily diagnosed in patients with cancer and metastatic bone disease and receiving intravenous administrations of nitrogen-containing bisphosphonates. If diagnosis or treatment is delayed, BRONJ can develop to a severe and devastating disease. Numerous studies have focused on BRONJ, with possible pathomechanisms identified to be oversuppression of bone turnover, ischemia due to antiangiogenetic...     »
Journal title abbreviation:
J Oral Maxillofac Surg
Year:
2010
Journal volume:
68
Journal issue:
5
Pages contribution:
1158-61
Language:
eng
Fulltext / DOI:
doi:10.1016/j.joms.2009.07.079
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20138420
Print-ISSN:
0278-2391
TUM Institution:
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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