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Titel:

Tumor necrosis factor-? enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Scherer, EQ; Yang, J; Canis, M; Reimann, K; Ivanov, K; Diehl, CD; Backx, PH; Wier, WG; Strieth, S; Wangemann, P; Voigtlaender-Bolz, J; Lidington, D; Bolz, SS
Abstract:
We sought to demonstrate that tumor necrosis factor (TNF)-?, via sphingosine-1-phosphate signaling, has the potential to alter cochlear blood flow and thus, cause ischemic hearing loss.We performed intravital fluorescence microscopy to measure blood flow and capillary diameter in anesthetized guinea pigs. To measure capillary diameter ex vivo, capillary beds from the gerbil spiral ligament were isolated from the cochlear lateral wall and maintained in an organ bath. Isolated gerbil spiral modiol...     »
Zeitschriftentitel:
Stroke
Jahr:
2010
Band / Volume:
41
Heft / Issue:
11
Seitenangaben Beitrag:
2618-24
Sprache:
eng
Volltext / DOI:
doi:10.1161/STROKEAHA.110.593327
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20930159
Print-ISSN:
0039-2499
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik
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