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Titel:

Platelets contribute to postnatal occlusion of the ductus arteriosus.

Dokumenttyp:
Journal Article; Article
Autor(en):
Echtler, K; Stark, K; Lorenz, M; Kerstan, S; Walch, A; Jennen, L; Rudelius, M; Seidl, S; Kremmer, E; Emambokus, NR; von Bruehl, ML; Frampton, J; Isermann, B; Genzel-Boroviczeny, O; Schreiber, C; Mehilli, J; Kastrati, A; Schwaiger, M; Shivdasani, RA; Massberg, S
Abstract:
The ductus arteriosus (DA) is a fetal shunt vessel between the pulmonary artery and the aorta that closes promptly after birth. Failure of postnatal DA closure is a major cause of morbidity and mortality particularly in preterm neonates. The events leading to DA closure are incompletely understood. Here we show that platelets have an essential role in DA closure. Using intravital microscopy of neonatal mice, we observed that platelets are recruited to the luminal aspect of the DA during closure....     »
Zeitschriftentitel:
Nat Med
Jahr:
2010
Band / Volume:
16
Heft / Issue:
1
Seitenangaben Beitrag:
75-82
Sprache:
eng
Volltext / DOI:
doi:10.1038/nm.2060
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19966813
Print-ISSN:
1078-8956
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik für Herz- und Gefäßchirurgie (Prof. Lange); Klinik und Poliklinik für Nuklearmedizin
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