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Title:

Histone Deacetylase (HDAC) 1 and 2 Expression and Chemotherapy in Gastric Cancer.

Document type:
Journal Article; Article
Author(s):
Mutze, K; Langer, R; Becker, K; Ott, K; Novotny, A; Luber, B; Hapfelmeier, A; Göttlicher, M; Höfler, H; Keller, G
Abstract:
BACKGROUND: Histone deacetylases (HDACs) modulate chromatin and may influence the effect of DNA-damaging drugs. We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as alternative treatment options. METHODS: HDAC1/2 expression was analyzed immunohistochemically in 127 pretherapeutic biopsy samples of neoadjuvant (platinum/5-fluorouracil) chemotherapy-treated G...     »
Journal title abbreviation:
Ann Surg Oncol
Year:
2010
Journal volume:
17
Journal issue:
12
Pages contribution:
3336-43
Language:
eng
Fulltext / DOI:
doi:10.1245/s10434-010-1182-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/20585871
Print-ISSN:
1068-9265
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie; Institut für Toxikologie und Umwelthygiene
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