Benutzer: Gast  Login
Titel:

A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Liang, X; Weigand, LU; Schuster, IG; Eppinger, E; van der Griendt, JC; Schub, A; Leisegang, M; Sommermeyer, D; Anderl, F; Han, Y; Ellwart, J; Moosmann, A; Busch, DH; Uckert, W; Peschel, C; Krackhardt, AM
Abstract:
T cells can recognize tumor cells specifically by their TCR and the transfer of TCR-engineered T cells is a promising novel tool in anticancer therapies. We isolated and characterized four allorestricted TCRs with specificity for the HER2/neu-derived peptide 369 (HER2(369)) demonstrating high peptide specificity. PBMCs transduced with especially one TCR, HER2-1, mediated specific tumor reactivity after TCR optimization suggesting that this TCR represents a potential candidate for targeting HER2...     »
Zeitschriftentitel:
J Immunol
Jahr:
2010
Band / Volume:
184
Heft / Issue:
3
Seitenangaben Beitrag:
1617-29
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.0902155
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/20042572
Print-ISSN:
0022-1767
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX